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Anti-Folr4 (Folate receptor 4), clone 5E12.2
Species Reactivity Key Applications Host Format Antibody Type
H, M WB Mouse Purified Monoclonal Antibody
Description:
Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2
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Specificity:
This antibody recognizes Folate receptor 4 (Folr4).
Molecular Weight:
~26 kDa
Epitope:
Unknown
Immunogen:
KLH-conjugated linear peptide corresponding to human Folate receptor 4 (Folr4).
Clone:
5E12.2
Isotype:
IgG1κ
Background Information:
Folates are necessary and critical components in the synthesis of proteins and nucleic acids, and have putative roles in the development of both the spinal canal and brain in the early stages of pregnancy (Yamaguchi, 2007). Folate receptor 4 (Folr4) is a recently discovered cell surface receptor for folic acid on T regulatory cells (Tregs). Studies have shown that Folr4 has an integral role in the maintenance of Treg cell function (Arase, 2009). Expression of Folr4 in Tregs is notably high, making it an opportune marker for the study of Treg cells. When studied in conjunction with CD4 and CD25, Folr4 also provides researchers with a marker to distinguish between Tregs and other T cells (Chai, 2008). Tregs are of interest in therapeutic, drug research due to their ability to actively suppress immune responses.
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Species Reactivity:
Human
Mouse
Species Reactivity Note:
Demonstrated to react with human and mouse.
Application Notes:
Western Blot (SNAP ID) Analysis: 1 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
Control:
Human thymus tissue lysate
Quality Assurance:
Evaluated by Western Blot in human thymus tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
A previous lot was shown to detect Folate Receptor 4 in mouse thymus tissue lysate.
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Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
A6ND01
Entrez Gene Number:
NP_001073955.1
Gene Symbol:
Folbp3
Folr4
FR-delta
Alternate Names:
folate receptor 4 (delta) homolog (mouse)
folate receptor 4 (delta) homolog
Folate receptor 4
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
SUBCELLULAR LOCATION: Secreted Potential.
PTM: Eight disulfide bonds are present Potential.
SEQUENCE SIMILARITIES: Belongs to the folate receptor family.
Product Name:
Anti-Folr4 (Folate receptor 4), clone 5E12.2
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μg
Format:
Purified
Host:
Mouse
Applications:
Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2 detects level of Fo |