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Anti-Beta Catenin, clone 7F7.2
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PRODUCT FAMILY INFORMATION
Nervous System Markers
The nervous system coordinates the voluntary and involuntary actions of the individual and transmits signals between different parts of the body.
The nervous system coordinates the voluntary and involuntary actions of the individual and transmits signals between different parts of the body.
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β-Catenin Antibodies, Kits & Proteins
Millipore’s β-catenin antibodies, kits and proteins are high quality, validated tools for beta-catenin research. See below for a list of β-catenin antibodies, from the expertise of Upstate & Chemicon.
Millipore’s β-catenin antibodies, kits and proteins are high quality, validated tools for beta-catenin research. See below for data and references for Millipore’s β-catenin antibodies. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-Beta Catenin Antibody, clone 7F7.2
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Trade Name:
Upstate (Millipore)
Specificity:
This antibody recognizes beta catenin.
Molecular Weight:
92 kDa
Immunogen:
Full length, GST-tagged recombinant beta catenin.
Clone:
7F7.2
Isotype:
IgG1κ
Background Information:
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
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Species Reactivity:
Human
Mouse
Rat
Application Notes:
Western Blot Analysis: 0.5-2 µg/mL of this lot detected beta catenin in HEK293 cell lysate.
Control:
HEK293 cell lysate, PC12 cell lysate, NIH/3T3 cell lysate
Quality Assurance:
Routinely evaluated by western blot on HEK293 cell lysate.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P35222
Entrez Gene Number:
NP_001895
Gene Symbol:
CTNNB
CTNNB1
FLJ25606
FLJ37923
DKFZp686D02253
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Alternate Names:
Beta Catenin
Catenin (cadherin-associated protein), beta 1
Usage Statement:
Unless otherwise stated in our catalog or other company documenta |