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Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal
Recommended Replacement for: Cat. # 05-921
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REFERENCES
Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-Selective Binding of the Antagonist [3H]UBP310.
Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E (2010) Mol Pharmacol.78:1036-45. Epub 2010 Sep 13.
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal
Replaces:
Cat. # 05-921
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes GluR6/7.
Molecular Weight:
115 kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 894-908 (C-terminus) of rat GluR6. The immunizing sequence is identical in human.
Clone:
NL904
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Control:
Mouse brain tissue, rat brain microsomal preparation, human brain lysates
Quality Assurance:
Routinely evaluated by immunoblot analysis.
Purification Method:
None
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Q13002
Entrez Gene Number:
NM_021956
Gene Symbol:
GRIK2
GLR6
EAA4
GluR-6
GLUR6
MGC74427
GluR6
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
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UniProt Summary:
FUNCTION: SwissProt: Q13002 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
SIZE: 908 amino acids; 102583 Da
SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the di |