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Anti-GluR1, clone C3T
Recommended Replacement for: 05-855
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REFERENCES
Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.
Jun Wang,Sami Ben Hamida,Emmanuel Darcq,Wenheng Zhu,Stuart L Gibb,Maria Fe Lanfranco,Sebastien Carnicella,Dorit Ron (2012) The Journal of neuroscience : the official journal of the Society for Neuroscience.32
Gonadectomy differentially regulates steroid receptor coactivator-1 and synaptic proteins in the hippocampus of adult female and male C57BL/6 mice.
Chen Bian,Kongjiang Zhu,Li Yang,Sen Lin,Shurong Li,Bingyin Su,Jiqiang Zhang (2012) Synapse (New York, N.Y.).66
Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory.
Nisticò, Robert, et al. (2012) Neuromolecular medicine, (2012)
Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II.
Mammen, A L, et al. (1997) J. Biol. Chem., 272: 32528-33 (1997)
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Chp IHC, IP, WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-GluR1 Antibody, clone C3T, rabbit monoclonal
Replaces:
05-855
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes GluR1, Mr 106 kDa.
Molecular Weight:
106 kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 858-868 (..TLPRNSGAGAS..) of human GluR1 (amino acids 840-850 of mature human GluR1)
Clone:
C3T
Isotype:
IgG
Background Information:
L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.
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Species Reactivity:
Human
Mouse
Rat
Chimpanzee
Species Reactivity Note:
Rat. Predicted to cross-react with human, mouse and chimpanzee.
Application Notes:
Western Blot Analysis:
A 1:5,000-1:10,000 dilution of this lot detected GluR1 from a rat brain microsomal preparation (Catalog # 12-144).
Immunoprecipitation: 2 μL of a previous lot immunoprecipitated GluR1 from rat brain microsomal preparation.
Immunohistochemistry: A previous lot of this antibody has been shown to detect GluR1 in human, mouse and rat tissues.
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Control:
Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144)
Quality Assurance:
Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144).
Presentation:
Cultured supernantant in 0.05% sodium azide
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P42261
Entrez Gene Number:
NM_000827.2
Gene Symbol:
GRIA1
GluR-A
GluR-1
GLUR1
GluR-K1
GLURA
HBGR1
GLUH1
MGC133252
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Usage Statement:
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