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Anti-phospho-GluR1 (Ser831),
clone N453
Recommended Replacement for: 05-823
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REFERENCES
Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor.
Barria, A, et al. (1997) J. Biol. Chem., 272: 32727-30 (1997)
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.
Roche, K W, et al. (1996) Neuron, 16: 1179-88 (1996)
The distribution of glutamate receptors in cultured rat hippocampal neurons: postsynaptic clustering of AMPA-selective subunits.
Craig, A M, et al. (1993) Neuron, 10: 1055-68 (1993)
Cellular localizations of AMPA glutamate receptors within the basal forebrain magnocellular complex of rat and monkey.
Martin, L J, et al. (1993) J. Neurosci., 13: 2249-63 (1993)
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Species Reactivity Key Applications Host Format Antibody Type
Ch, H, M, R WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-phospho-GluR1 (Ser831) Antibody, clone N453, rabbit monoclonal
Replaces:
05-823
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes GluR1 phosphorylated on Serine 831.
Molecular Weight:
106 kDa
Immunogen:
KLH-conjugated, synthetic peptide containing the sequence ...QQ[pS]IN… in which pS corresponds to phospho-serine at position 831 of the GluR1 mature chain. Sequence is identical in human, rat, mouse and chicken.
Modifications:
Phosphorylation
Clone:
N453
Isotype:
IgG
Background Information:
L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.
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Species Reactivity:
Chicken
Human
Mouse
Rat
Species Reactivity Note:
Predicted cross-reactivity with human, mouse and chicken
Application Notes:
Western Blot Analysis:
A 1:1,000-1:4,000 dilution of this lot detected phosphorylated GluR1 from a rat brain microsomal preparation (Catalog # 12-144).
Control:
Rat brain
Quality Assurance:
routinely evaluated by western blot
Presentation:
Cultured supernantant in 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap.
UniProt Number:
P42261
Entrez Gene Number:
NP_000818
Gene Symbol:
GRIA1
GluR-A
GluR-1
GLUR1
GluR-K1
GLURA
HBGR1
GLUH1
MGC133252
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Alternate Names:
AMPA 1
AMPA-selective glutamate receptor 1
Glutamate receptor ionotropic, AMPA 1
glutamate receptor, ionotropic, AMPA 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consu |