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Anti-dimethyl-Histone H3 (Lys9), clone MC554
Recommended Replacement for: Cat. # 05-768. 05-768 will only be availabe on a custom basis.
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PRODUCT FAMILY INFORMATION
Histone H3 Antibodies, Proteins and Kits
Millipore’s Histone H3 antibodies demonstrate specificity against histone H3. See below for acetyl-, methyl-, phospho- histone H3 Antibodies and Proteins, based on the expertise of Upstate & Chemicon.
Millipore’s Anti-Histone H3 Antibody demonstrates specificity against Histone H3. See below for data, references and related products for Histone H3. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Species Reactivity Key Applications Host Format Antibody Type
H IF, WB, PIA, DB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-dimethyl-Histone H3 (Lys9) Antibody, clone MC554, rabbit monoclonal
Replaces:
Cat. # 05-768. 05-768 will only be availabe on a custom basis.
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Trade Name:
Upstate (Millipore)
Specificity:
Histone H3 dimethylated on lysine 9
Molecular Weight:
17kDa
Immunogen:
Peptide containing dimethyl-lysine at residue 9 of human histone H3
Modifications:
Methylation
Clone:
MC554
Isotype:
IgG
Background Information:
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure.
The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
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Species Reactivity:
Human
Species Reactivity Note:
Broad species cross reactivity is expected
Control:
Acid-extracted proteins from log phase HeLa cells
Quality Assurance:
routinely evaluated by immunoblot on acid-extracted proteins from HeLa cells; the antibody did not detect unmethylated recombinant Histone H3 (Catalog #14-494)
Presentation:
Cultured supernantant in 0.05% sodium azide
Storage Conditions:
Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Q16695
Entrez Gene Number:
NP_003484
Gene Symbol:
HIST3H3
H3FT
MGC126886
H3t
MGC126888
H3T
H3/g
H3.4
H3/t
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Alternate Names:
H3K4me2
Histone H3 (di methyl K4)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunofluorescence
Western Blotting
Peptide Inhibition Assay
Dot Blot
Entrez Gene Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of appr |