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Anti-CREB Antibody, clone NL904, rabbit monoclonal
Recommended Replacement for: 05-767
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PRODUCT FAMILY INFORMATION
CREB Antibodies & Kits
Millipore’s CREB Antibodies demonstrate specificity against CREB, which acts through cAMP response elements. See below for related products for CREB based on the expertise of Upstate & Chemicon.
Millipore’s Anti- CREB Antibodies demonstrates specificity against CREB. See below for data, references and related products for CREB. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-CREB Antibody, clone NL904, rabbit monoclonal
Replaces:
05-767
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes CREB.
Molecular Weight:
Mr ~43 kDa
Epitope:
a.a. 5-24
Immunogen:
peptide (C-SGAENQQSGDAAVTEAENQQ) corresponding to amino acids 5-24 of human CREB
Clone:
NL904
Isotype:
IgG
Background Information:
CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Broad species cross-reactivity expected due to sequence homology
Control:
HeLa nuclear extract
Included Positive Antigen Control: Catalog # 12-309, HeLa nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
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Quality Assurance:
Routinely evaluated by immunoblot on HeLa nuclear extract
Presentation:
Cultured supernantant in 0.05% sodium azide
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap. It is suggested product be sub-aliquoted to avoid repeated freeze / thaw cycles.
UniProt Number:
P16220
Entrez Gene Number:
NM_134442
Gene Symbol:
CREB1
CREB
MGC9284
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes a trans |