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Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
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REFERENCES
Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway
Lucas, P C, et al (2001) J Biol Chem, 276:19012-9 (2001)
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
Uren, A G, et al (2000) Mol Cell, 6:961-7 (2000)
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
Zhou, Honglin, et al (2004) Nature, 427:167-71 (2004)
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
Dierlamm, J, et al (1999) Blood, 93:3601-9 (1999)
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Species Reactivity Key Applications Host Format Antibody Type
H FC, IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Human MALT1/MLT1 (N-Term).
Immunogen:
A synthetic peptide corresponding to residues in the N-term of human MALT1. This antibody is predicted to detect splice isoform 2 based on sequence analysis.
Clone:
EP603Y
Background Information:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).
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Species Reactivity:
Human
Species Reactivity Note:
Human (positive control: Jurkat cell lysate)
Application Notes:
WB: 1:2,000
Flow Cytometry: 1:30
IP: 1:50
Presentation:
Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Conditions:
Store at -20 °C. Stable for 12 months from date of receipt.
UniProt Number:
Q9UDY8
Entrez Gene Number:
NM_006785.2
NM_173844.1
Gene Symbol:
MALT1
paracaspase
MLT1
MLT
Paracaspase
DKFZp434L132
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Alternate Names:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor |