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Anti-RhoG, clone 1F3 B3 E5
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REFERENCES
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
Kristin Franke,Wolfgang Otto,Sascha Johannes,Jan Baumgart,Robert Nitsch,Stefan Schumacher (2012) The EMBO journal.31
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Mouse Purified Monoclonal Antibody
Description:
Anti-RhoG Antibody, clone 1F3 B3 E5
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes RhoG
Molecular Weight:
21 kDa
Immunogen:
KLH synthetic peptide encompassing amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180)
Clone:
clone 1F3 B3 E5
Isotype:
IgG2bκ
Background Information:
RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac.
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Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by western blot on NIH/3T3 cell lysate.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG2b in storage buffer containing PBS with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.
UniProt Number:
P84095
Entrez Gene Number:
NM_001665
Gene Symbol:
RHOG ras homolog gene family, member G (rho G)
Rho G
ARHG
MGC125835
MGC125836
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Alternate Names:
ARHG
RHOG ras homolog gene family, member G (rho G)
MGC125835
MGC125836
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.[supplied by OMIM]
UniProt Summary:
FUNCTION: Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
SUBUNIT STRUCTURE:Interacts with SGEF.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
Sequence similarities: Belongs to the small GTPase superfamily. Rho family.
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Brand Family:
Upstate
Product Name:
Anti- |