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Anti-Farnesyltransferase Antibody, α subunit (FNTA), clone 2418
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REFERENCES
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
(2006) Delarue, F L, et al
Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations
Lubet, Ronald A, et al (2006) Mol Cancer Ther, 5:1073-8 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H WB Mouse Purified Monoclonal Antibody
Description:
Anti-Farnesyltransferase Antibody, α subunit (FNTA), clone 2418
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Trade Name:
Upstate (Millipore)
Specificity:
Specific to the alpha subunit of farnesyl transferase.
Molecular Weight:
44 kDa
Immunogen:
Full length GST-farnesyltransferase, alpha subunit protein
Clone:
2418
Isotype:
IgG1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein A purfied
Presentation:
100 μL of protein A purified mouse monoclonal IgG1κ in PBS with 0.1% sodium azide.
Storage Conditions:
Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P49354
Entrez Gene Number:
NM_001018676.1
NM_001018677.1
NM_002027.2
Gene Symbol:
FNTA
FPTA
MGC99680
FTase-alpha
GGTase-I-alpha
PGGT1A
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Alternate Names:
farnesyltransferase, CAAX box, alpha, FTase-alpha, GGTase-I-alpha, farnesyltransferase alpha-subunit, ras proteins prenyltransferase alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Prenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms.
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UniProt Summary:
FUNCTION: SwissProt: P49354 # Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
SIZE: 379 amino acids; 44409 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit.
SIMILARITY: SwissProt: P49354 ## Belongs to |