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Anti-SREBP1 Antibody, clone 2121
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REFERENCES
Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding
Punga, Tanel, et al (2006) J Biol Chem, 281:25278-86 (2006)
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization
Wang, X, et al (1993) J Biol Chem, 268:14497-504 (1993)
Species Reactivity Key Applications Host Format Antibody Type
H WB Mouse Purified Monoclonal Antibody
Description:
Anti-SREBP1 Antibody, clone 2121
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Trade Name:
Upstate (Millipore)
Specificity:
Reacts with the basic helix-loop-helix leucine zipper (bHLH-ZIP) of SREBP.
Molecular Weight:
126 kDa
Immunogen:
Recombinant His-tagged human SREBP-1a protein encompassing amino acids 301-407.
Clone:
2121
Isotype:
IgG1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein A purfied
Presentation:
100 μL (1 mg/mL) of protein A purified mouse monoclonal IgG1 in PBS with 0.1% sodium azide.
Storage Conditions:
Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P36956
Entrez Gene Number:
NM_001005291.1
NM_004176.3
Gene Symbol:
SREBF1
SREBP1
SREBP-1
Alternate Names:
SREBF1, sterol regulatory element binding transcription factor 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: P36956 # Transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity, binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the transcription of genes for sterol biosynthesis and the LDL receptor gene.
SIZE: 1147 amino acids; 121645 Da
SUBUNIT: |