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Anti-SUMO-1 Antibody, rabbit monoclonal
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REFERENCES
Ubiquitin and its kin: how close are the family ties?
Jentsch, S and Pyrowolakis, G (2000) Trends Cell Biol., 10: 335-42 (2000)
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
Saitoh, H and Hinchey, J (2000) J Biol Chem, 275:6252-8 (2000)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-SUMO-1 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region composed of residues at the C-terminus of human SUMO-1.
Molecular Weight:
18/90 kDa
Immunogen:
KLH-conjugated synthetic peptide composed of residues at the C-terminus of human SUMO-1.
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P63165
Entrez Gene Number:
NM_001005781.1
NM_001005782.1
NM_003352.4
Gene Symbol:
SUMO1
OFC10
DAP-1
sentrin
PIC1
SUMO-1
Sentrin
UBL1
SENP2
SMT3H3
SMT3
GMP1
SMT3C
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
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UniProt Summary:
FUNCTION: SwissProt: P63165 # Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates |