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Anti-TRAF6 (CT) Antibody, rabbit monoclonal
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REFERENCES
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
Wong, B R, et al. (1998) J. Biol. Chem., 273: 28355-9 (1998)
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
Ishida, T, et al (1996) J Biol Chem, 271:28745-8 (1996)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IF, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-TRAF6 (CT) Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region composed of residues at the C-terminus of human TRAF6.
Molecular Weight:
58 kDa
Immunogen:
KLH-conjugated synthetic peptide composed of residues at the C-terminus of human TRAF6.
Isotype:
IgG
Background Information:
TNF receptor-associated factor 6 is a member of the TNF receptor associated factor (TRAF) protein family. TNF receptor-associated factor 6 proteins play an important role as adaptor protein for cell survival, proliferation, differentiation and stress responses. TNF receptor-associated factor 6 has unique binding behavior that result in signaling responses from the interleukin-1 receptor (IL-1R) toll-like receptor. TNF receptor-associated factor 6 mediates signaling indirectly with IL-1R/TLR through IRAK. This leads to activation of NF-κB and MAP kinase signaling pathways though downstream association with the TAB/TAK-1 complex. TNF receptor-associated factor 6 is also involved in the activation of Akt/PKB and serves as a direct E3 ligase which is essential for Akt ubiquitination.
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Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
Q9Y4K3
Entrez Gene Number:
NM_004620.2
NM_145803.1
Gene Symbol:
TRAF6
RNF85
MGC:3310
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunofluorescence
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with vario |