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Anti-Bcl-10 Antibody, rabbit monoclonal
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REFERENCES
Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue
Wotherspoon, A C, et al (1992) Cancer Genet Cytogenet, 58:35-8 (1992)
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase
Ruefli-Brasse, Astrid A, et al (2003) Science, 302:1581-4 (2003)
Species Reactivity Key Applications Host Format Antibody Type
Human Only FC, IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Bcl-10 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region near the N-terminus domain of human Bcl-10.
Molecular Weight:
32 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bcl-10.
Isotype:
IgG
Species Reactivity:
Human Only
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
O95999
Entrez Gene Number:
NM_003921.3
Gene Symbol:
BCL10
mE10
CARMEN
cCARMEN
Bcl-10
Cellular-E10
CLAP
CIPER
c-E10
hCLAP
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
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UniProt Summary:
FUNCTION: SwissProt: O95999 # Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex.
SIZE: 233 amino acids; 26252 Da
SUBUNIT: Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C- terminal domain. Interac |