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Anti-PAK3 Antibody, rabbit monoclonal
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REFERENCES
The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus
Boda, Bernadett, et al (2004) J Neurosci, 24:10816-25 (2004)
A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases
Rousseau, Veronique, et al (2003) J Biol Chem, 278:3912-20 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IF, IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-PAK3 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the N-terminus of PAK3.
Molecular Weight:
65 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to N-terminus of human PAK3 (p21-Activated Kinase 3).
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
UniProt Number:
O75914
Entrez Gene Number:
NM_002578.2
Gene Symbol:
PAK3
OPHN3
PAK3beta
OTTHUMP00000062894
hPAK3
MRX47
MRX30
bPAK
oligophrenin-3
CDKN1A
PAK-3
Beta-PAK
Oligophrenin-3
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Alternate Names:
p21-activated Kinase 3, p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunofluorescence
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
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UniProt Summary:
FUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
COFACTOR: Magnesium (By similarity).
SIZE: 559 amino acids; 62310 Da
SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
PTM: Autophosphorylated when activated by CDC42/p21.
DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental reta |