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Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal
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REFERENCES
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
Ohanna, Mickael, et al (2005) Nat Cell Biol, 7:286-94 (2005)
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
Bachmann, Rebecca A, et al (2006) J Biol Chem, 281:7357-63 (2006)
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
Chiang, Gary G and Abraham, Robert T (2005) J Biol Chem, 280:25485-90 (2005)
Species Reactivity Key Applications Host Format Antibody Type
H IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the p70 S6 Kinase when phosphorylated on Thr421 and Ser424.
Molecular Weight:
70 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to the region surrounding Thr421 and Ser424 of human p70 S6 Kinase.
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Species Reactivity Note:
Not believed to react with mouse or rat.
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
P23443
Entrez Gene Number:
NM_003161.2
Gene Symbol:
RPS6KB1
p70-alpha
p70S6k
p70-S6K
p70
S6K
S6Kalpha)
P70S6K
STK14A
S6K1
p70(S6K)-alpha
PS6K
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Alternate Names:
RPS6KB1 ribosomal protein S6 kinase, 70kDa, PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
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UniProt Summary:
FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
SIZE: 525 amino acids; 59140 Da
SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: SwissProt: P23443 ## Belongs to the protein ki |