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Anti-phospho-Lyn (Tyr507) Antibody, rabbit monoclonal
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REFERENCES
Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein.
Brunati, Anna Maria, et al. (2005) J. Biol. Chem., 280: 21029-35 (2005)
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation
Kaabeche, Karim, et al (2004) J Biol Chem, 279:36259-67 (2004)
Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells
Kannan, Shibichakravarthy, et al (2006) Eur J Immunol, 36:1739-52 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IH(P), IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-phospho-Lyn (Tyr507) Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the Lyn phosphorylated at Tyr507.
Molecular Weight:
53/56 kDa
Immunogen:
KLH-conjugated synthetic phospho-peptide corresponding to residues surrounding Tyrosine 507 of human Lyn.
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Suggested dilutions:
Immunoblot Analysis: 1:5,000
Immunoprecipitation: 1:80
Immunohistochemistry: A 1:50-1:100
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P07948
Entrez Gene Number:
NM_002350.1
Gene Symbol:
LYN
FLJ26625
JTK8
Alternate Names:
JTK8
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry (Paraffin)
Immunoprecipitation
Western Blotting
UniProt Summary:
SIZE: 512 amino acids; 58574 Da
SUBUNIT: Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1.
TISSUE SPECIFICITY: Expressed in primary neuroblastoma tumors.
SIMILARITY: SwissProt: P07948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
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Brand Family:
Upstate
Product Name:
Anti-phospho-Lyn (Tyr507) Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applications:
This Anti-phospho-Lyn (Tyr507) Antibody, Rabbit is validated for us |