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Anti-IRR α subunit Antibody, rabbit monoclonal
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REFERENCES
Comparative analysis of the signaling capabilities of the insulin receptor-related receptor
Klammt, Jurgen, et al (2005) Biochem Biophys Res Commun, 327:557-64 (2005)
Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary
Dissen, Gregory A, et al (2006) Endocrinology, 147:155-65 (2006)
Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
Weber, Axel, et al (2003) Clin Cancer Res, 9:5683-92 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IRR α subunit Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the IRR alpha subunit
Molecular Weight:
80/144 kDa
Immunogen:
KLH-conjugated synthetic peptide near the N-terminus of human IRR alpha subunit.
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Immunoblot Analysis: A 1:2,000 dilution of the lot detected IRR alpha subunit in lysates from PC12, MCF-7, HeLa and SHSY5Y cells.
Immunohistochemistry:
A 1:50-1:100 dilution of this antibody was used in immunohistochemical analysis of Paraffin-embedded human kidney tissue using the anti-IRR alpha subunit antibody.
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Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
P14616
Entrez Gene Number:
NM_014215.1
Gene Symbol:
INSRR
IRR
Alternate Names:
INSRR
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
SIZE: 1297 amino acids; 143720 Da
SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
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Brand Family:
Upstate
Product Name:
Anti-IRR α subunit Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applications:
Anti-IRR α subunit An |