|
Anti-IRAK3 Antibody, rabbit monoclonal
Close
REFERENCES
Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.
del Fresno, Carlos, et al. (2005) J. Immunol., 174: 3032-40 (2005)
Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.
Escoll, Pedro, et al. (2003) Biochem. Biophys. Res. Commun., 311: 465-72 (2003)
Identification and characterization of murine IRAK-M
Rosati, Olaf and Martin, Michael U (2002) Biochem Biophys Res Commun, 293:1472-7 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IRAK3 Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the C-term domain of IRAK3.
Molecular Weight:
68 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to residues in the C-term of human IRAK-3
Isotype:
IgG
Species Reactivity:
Human
Mouse
Application Notes:
Immunoblot Analysis: A 1:2,000 dilution of the lot detected IRAK3 CT in lysates from A431 cells.
Immunoprecipitation:
A 1:50 dilution of this antibody immunoprecipitated IRAK3 CT using protein G:agarose beads.
View All »
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q9Y616
Entrez Gene Number:
NM_007199.1
Gene Symbol:
IRAK3
IRAKM
IRAK-3
ASRT5
IRAK-M
View All »
Alternate Names:
IRAKM
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunoprecipitation
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q9Y616 # Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
COFACTOR: Magnesium.
SIZE: 596 amino acids; 67753 Da
TISSUE SPECIFICITY: Expressed predominantly in peripheral blood lymphocytes.
DISEASE: SwissProt: Q9Y616 # Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
SIMILARITY: SwissProt: Q9Y616 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
View All »
Brand Family:
Upstate
Product Name:
Anti-IRAK3 Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applic
|