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Anti-Glycogen Synthase CT Antibody, rabbit monoclonal
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REFERENCES
The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.
Gaster, Michael, et al. (2004) Biochem. Biophys. Res. Commun., 319: 1235-40 (2004)
Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins
Poulsen, Pernille, et al (2005) Diabetes, 54:1289-96 (2005)
Association of muscle glycogen synthase polymorphism with insulin resistance in type 2 diabetic patients
Motoyama, Koka, et al (2003) Metab Clin Exp, 52:895-9 (2003)
Determinants of the nucleocytoplasmic shuttling of muscle glycogen synthase
Cid, Emili, et al (2005) FEBS J, 272:3197-213 (2005)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R FC, IF, IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Glycogen Synthase CT Antibody, rabbit monoclonal
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Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes the C-term domain of Glycogen Synthase
Molecular Weight:
85 kDa
Immunogen:
KLH-conjugated A synthetic peptide corresponding to residues in the C-terminus of the human glycogen synthase
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Suggested Dilutions:
Immunoblot Analysis: 1:50,000
Immunoprecipitation: 1:150
Flow Cytometry: 1:50
Immunohistochemistry: 1:250-1:500
Immunfluorescence Staining: 1:250-1:500
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Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA, and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P13807
Entrez Gene Number:
NM_002103.3
Gene Symbol:
GYS1
Glycogen
GYS
GSY
Alternate Names:
GYS, GSY
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Immunofluorescence
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
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Entrez Gene Summary:
Glycogen is a high molecular mass polysaccharide that serves as a repository of glucose for use in times of metabolic need. Glycogen synthase (EC 2.4.1.11) catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages (Pederson et al., 2004 [PubMed 15282316]).[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: P13807 # Transfers the glycosyl residue from UDP-Glc to the nonreducing end of alpha-1,4-glucan.
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