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Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
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REFERENCES
Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats.
Silje Skrede,Johan Fernø,María Jesús Vázquez,Sveinung Fjær,Tina Pavlin,Niclas Lunder,Antonio Vidal-Puig,Carlos Diéguez,Rolf Kristian Berge,Miguel López,Vidar Martin Steen (2012) The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).15
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis.
Mao, Jianqiang, et al. (2006) Proc. Natl. Acad. Sci. U.S.A., 103: 8552-7 (2006)
Inhibition of acetyl-CoA carboxylase isoforms by pyridoxal phosphate
Lee, Weissy M, et al (2005) J Biol Chem, 280:41835-43 (2005)
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
Abu-Elheiga, Lutfi, et al (2005) Proc Natl Acad Sci USA, 102:12011-6 (2005)
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Acetyl CoA Carboxylase 1
Molecular Weight:
265 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to human Acetyl CoA Carboxylase 1
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Storage Conditions:
Stable for 2 years at -20°C from date of shipment.
UniProt Number:
Q13085
Entrez Gene Number:
NM_198834.1
NM_198836.1
NM_198837.1
NM_198838.1
NM_198839.1
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Gene Symbol:
ACACA
ACC-alpha
ACCA
ACC
ACC1
ACAC
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Alternate Names:
ACACA, ACAC, ACC, ACC1, ACCA, acetyl-Coenzyme A carboxylase alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogene |