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Anti-Lyn, clone 10A6.2
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Ch WB Mouse Ascites Monoclonal Antibody
Description:
Anti-Lyn Antibody, clone 10A6.2
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).
Molecular Weight:
58 kDa
Epitope:
C-Terminus
Immunogen:
KLH conjugated linear peptide corresponding to the C-terminus of Lyn.
Clone:
10A6.2
Isotype:
IgG1κ
Background Information:
Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.
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Species Reactivity:
Human
Mouse
Rat
Chicken
Species Reactivity Note:
Human.
Predicted reactivity with mouse, rat and chicken based on 100% sequence homology.
Application Notes:
Western Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
Control:
A431 cell lysate
Quality Assurance:
Routinely evaluated by western blot on A431 cell lysate.
Presentation:
Mouse monoclonal IgG1κ ascites containing 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt.
UniProt Number:
Q6NUK7
Entrez Gene Number:
NP_001104567
Gene Symbol:
JTK8
Lyn
FLJ26625
Alternate Names:
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.
SIMILARITY: Contains 1 protein kinase domain.
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Product Name:
Anti-Lyn, clone 10A6.2
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Ascites
Host:
Mouse
Applications:
Anti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB. |