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Anti-Ubiquitinylated proteins Antibody, clone FK1
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REFERENCES
Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration.
Sharma, Manu, et al. (2012) Sci Transl Med, 4: 147ra113 (2012)
z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, Romeo F, Maffei M, Melotti A, Giaretti W, Corte G, Castagnola P (2009) Molecular cancer research : MCR.7:1822-34
PI31 is a modulator of proteasome formation and antigen processing.
Zaiss, Dietmar M W, et al. (2002) Proc. Natl. Acad. Sci. U.S.A., 99: 14344-9 (2002)
Transient aggregation of ubiquitinated proteins during dendritic cell maturation.
Lelouard, Hugues, et al. (2002) Nature, 417: 177-82 (2002)
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Species Reactivity Key Applications Host Format Antibody Type
A WB, IHC Mouse Purified Monoclonal Antibody
Description:
Anti-Ubiquitinylated proteins Antibody, clone FK1
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Trade Name:
Upstate (Millipore)
Product Overview:
Ubiquitin is a polypeptide of 76 amino acid residues, being a very highly conserved and widely distributed protein in all eukaryotic cells. It has been proposed that ubiquitin plays important roles in various biological processes such as the regulation of cell cycle, DNA replication, DNA repair, stress response, apoptosis, signal transduction, and the biogenesis of ribosome, nucleosome, peroxisome and myofibrils. In these processes, ubiquitin functions as both a signal for protein degradation and as a chaperone promoting the formation of organelles.
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Specificity:
Recognizes only poly-ubiquitinylated proteins and not mono-ubiquitinylated proteins or free ubiquitin.
Immunogen:
Poly-ubiquitinylated-lysozyme.
Clone:
FK1
Isotype:
IgM
Species Reactivity:
All
Presentation:
100 µL of concentration 1mg/mL purified immunoglobulin in PBS containing 0.1% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at 2-8°C from date of shipment for up to 12 months.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
Brand Family:
Upstate
Product Name:
Anti-Ubiquitinylated proteins Antibody, clone FK1
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Mouse
Applications:
Anti-Ubiquitinylated proteins Antibody, clone FK1 is an antibody against Ubiquitinylated proteins for use in WB, IH. |