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Anti-Catenin δ-1 (p120 Catenin), cloneYE372
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Species Reactivity Key Applications Host Format Antibody Type
H, not R, not M FC, ICC, IHC, IH(P), IP, WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-Catenin δ-1 (p120 Catenin) Antibody, cloneYE372, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
This antibody recognizes Catenin 1 (p120 Catenin) at the N-terminus.
Molecular Weight:
120 kDa
Immunogen:
Synthetic peptide directed against the N-terminus of human Catenin δ-1.
Clone:
YE372
Isotype:
IgG
Background Information:
Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. Delta-1-catenin is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.
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Species Reactivity:
Human
Species Reactivity Note:
Proven to react with human. Not expected to react with mouse or rat.
Non-Reactive Species:
Rat
Mouse
Application Notes:
Flow Cytometry:
A 1:50 dilution of a previous lot was used in FC.
Immunoprecipitation:
A 1:80 dilution of a previous lot was used in IP.
Immunocytochemistry:
A 1:250 dilution of a previous lot was used in IC.
Immunohistochemistry: A 1:100-250 dilution of a previous lot was used in IH.
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Control:
HeLa whole cell lysate
Quality Assurance:
Routinely evaluated by Western Blot on HeLa whole cell lysate.
Western Blot Analysis:
A 1:250-1:1000 dilution of this lot was used to detect p120 Catenin in HeLa whole cell lysate.
Purification Method:
Unpurified
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
O60716
Entrez Gene Number:
NM_001085458.1
Gene Symbol:
CAS
CTNND
KIAA0384
P120CAS
P120CTN
p120
p120(cas)
p120(ctn)
p120cas
p120ctn
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Alternate Names:
Cadherin-associated Src substrate
catenin (cadherin-associated protein), delta 1
catenin, delta 1
p120 catenin
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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