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TPO, murine recombinant
Stimulates the proliferation and maturation of megakaryocytes
Product Overview
Alternate Names / Synonyms: Murine TPO, TPO, m-TPO, rm-TPO, recombinant murine TPO, recombinant TPO, TPO
Gene Symbol: TPO
Accession #: P40226
Gene ID: 21832
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized from 10 mM Tris, pH 8.0
Molecular Weight: 18.7 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 10⁶ units/mg.
Reconstitution Instructions: Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Further dilutions of this solution should be made into buffer containing carrier protein or medium containing serum. This solution can be stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulation levels of platelets in vivo. The murine TPO is a soluble 18.7 kDa protein containing 174 amino acid residues, which comprises the receptor binding domain of the Mpl-ligand protein.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |