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TWEAK, human recombinant
An apoptosis inducer
Product Overview
Alternate Names / Synonyms: APO3L, DR3LG, TWEAK, TNFSF12
Gene Symbol: TNFSF12
Accession #: O43508
Gene ID: 8742
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 0.1 M L-Arg.
Molecular Weight: 17.0 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 10 ng/ml.
Reconstitution Instructions: Reconstitute in 10 mM Sodium Phosphate (pH 7.5) to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many other members of the TNF family, is able to induce interleukin-8 synthesis in a number of cell lines. The recombinant human TWEAK is a 17.0 kDa protein, comprising the TNF-like extraCellular domain of TWEAK
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |