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TPO, human recombinant
Stimulates the proliferation and maturation of megakaryocytes
Product Overview
Alternate Names / Synonyms: TPO, human recombinant
Gene Symbol: TPO
Accession #: P07202
Gene ID: 7173
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized with no additives
Molecular Weight:
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/ml, corresponding to a specific activity of >1 x 10⁶ IU/mg.
Reconstitution Instructions: Reconstitution in purified water to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA).
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |