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Serum Retinol Binding Protein 4 Blocking Peptide
Cayman Chemical Item Number 10007682
Description Peptide sequence:human amino acids 28-37 · To be used in conjunction with Cayman’s sRBP4 Polyclonal Antibody (Catalog No. 10007681) to block protein-antibody complex formation during immunochemical analysis of sRBP4. Serum retinol binding protein (sRBP4) binds one equivalent of vitamin A and is one of the major retinol carriers found in the blood of mammals.1↗,2↗ Human RBP4 is a monomeric 21 kDa β-sheet-rich protein that contains three disulfide bonds and belongs to the lipocalin protein family.3↗ sRBP4 is synthesized and sequestered in hepatocytes until retinol binding triggers its secretion.3↗ In plasma, sRBP4 typically forms a 1:1 complex with the 55 kDa tetrameric protein transthyretin (TTR) which prevents RBP from being removed from the plasma by glomerular filtration.4↗ Recent studies have shown that sRBP4 is an adipocyte-derived “signal” that may contribute to the pathogenesis of type 2 diabetes.5↗,6↗ Elevation of sRBP4 causes systemic insulin resistance whereas reduction of serum concentrations improves insulin action.5↗,7↗,8↗ The highest known concentrations of this protein exist in serum, liver, and skeletal muscle.8↗,9↗,10↗
Synonyms
sRBP4 Blocking Peptide
Plasma Retinol Binding Protein 4 Blocking Peptide
pRBP Blocking Peptide
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere |