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LDL Receptor Blocking Peptide
Cayman Chemical Item Number 10007672
Description
Cholesterol is an essential element of cell membranes and is carried around the body packaged in lipoproteins, mostly low-density lipoprotein (LDL). The LDL receptors (LDLR) are complex glycoproteins located on cell membranes to scavenge LDL from the blood and regulate plasma LDL cholesterol. LDLRs contain five primary domains: the ligand binding domain, the homology with the EGF precursor domain, the O-link sugars domain, the membrane-spanning region, and a cytoplasmic tail.1↗ In humans, more than 60% of the LDLRs are found in the liver.2↗ LDLRs expression is under hormonal control both in vivo and in vitro. Mutations in the LDLR gene cause disorders such as familial hypercholesterolemia and atherosclerosis.1↗
Synonyms
LDLR Blocking Peptide
Low-density Lipoprotein Receptor Blocking peptide
Formulation 200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere |