|
LDL Receptor Polyclonal Antibody
Cayman Chemical Item Number 10007665
Description Antigen:Synthetic peptide from mouse LDL receptor amino acids 499-511 (SVADTKGVKRRTL) · Host:rabbit · Application(s):ICC and WB · Cholesterol is an essential element of cell membranes and is carried around the body packaged in lipoproteins, primarily low-density lipoproteins (LDLs). The LDL receptors (LDLRs) are cell surface glycoproteins that scavenge LDL from the blood and regulate plasma LDL cholesterol. LDLRs contain five primary domains: the ligand binding domain, the homology with the EGF precursor domain, the O-linked sugars domain, the membrane-spanning region, and a cytoplasmic tail.1↗ In humans, more than 60% of the LDL R3 are found in the liver.2↗ LDLR expression is under hormonal control both in vivo and in vitro. Mutations in the LDLR gene cause disorders such as familial hypercholesterolemia and atherosclerosis.1↗ Murine LDLR is 864 amino acids in length with an estimated molecular weight of 95 kDa. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.1↗ Cayman’s LDL receptor polyclonal antibody detects both glycosylated and unglycosylated proteins in tissue/cell samples such as liver, HepG2, and RAW 264.7 cells.
Synonyms
Low Density Lipoprotein Receptor
LDLR
Formulation Peptide affinity-purified IgG
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity
Human LDL receptor
Mouse LDL receptor
Rat LDL receptor |