Geneticin (G418) Sulfate (CAS 108321-42-2) (Based on popularity) Synonym: Antibiotic G418 Application: An aminoglycoside antibiotic CAS Number: 108321-42-2 Purity: ≥98% Molecular Weight: 692.71 Molecular Formula: C20H40N4O10•2H2SO4 Description Geneticin (G418) Sulfate is an aminoglycoside antibiotic that has originally been derived from Micromonospora rhodoranga NRRL 5326. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that geneticin sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosome and inhibits the elongation cycle. Further studies report that geneticin sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells. Additional Images Geneticin (G418) Sulfate: sc-29065. Cultured HeLa cells treated with 0μg/ml (A) and 8μg/ml (B) Geneticin (G418) Sulfate, for 48 hours and subsequently stained with Trypan Blue: sc-216028 to check for cell viability. Usage • Potency: ≥700 μg/mg Technical Information Appearance: Powder Physical State: Solid Solubility: Soluble in water (50 mg/ml) and aqueous buffers. Storage: Store at 4° C Boiling Point: 1012.1 °C at 760 mmHg (Predicted) Safety and Reference Information WGK Germany: 3 PubChem CID: 16760463 MDL Number: MFCD00058314 SMILES: C[C@H]([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2 O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O )O For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
