InSolution GSK-3 Inhibitor XVI, CHIR99021

InSolution™ GSK-3 Inhibitor XVI, CHIR99021
6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile
A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. The solid form of this compound (Cat. No. 361559) is also available.
产品信息
Form  Liquid
Formulation  A 25 mM (5 mg/430 µL) solution of GSK-3 Inhibitor XVI, CHIR99021 (Cat. No. 361559) in DMSO.
Primary Target  GSK-3 α and β
Primary Target IC50  10 and 6.7 nM against GSK-3&alpha
Molar mass  465.3
Protect from Light  是的
Hygrocopic  是的
Avoid freeze/thaw  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥95% by HPLC
CAS number  252917-06-9
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Irritant