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InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
eIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
产品信息
Form Liquid
Formulation A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
Primary Target eIF4E
Primary Target Ki 25 µ
Molar mass 451.3
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC (sum of two isomers)
Chemical formula C18H12Cl2N4O4S
CAS number 315706-13-9
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
安全标示
S Phrase S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase R: 36/38
Irritating to eyes and skin. |