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Dopamine Receptor Antagonist II, Thioridazine, HCl
A phenothiazine class antipsychotic and dopamine receptor (DR) antagonist that is reported to exhibit CSCs- (cancer stem cells) differentiating (EC50 ≤9.4 µM for v1H9) and anti-leukemic activity, without affecting non-neoplastic H9 hESC, adult fibroblast-derived iPSC, or HSPCs (hematopoietic stem-progenitor cells). However, Thioridazine's high effective concentration (10 µM) against cancer cells suggests that other unidentified cellular targets/mechanisms in addition to DR antagonism may be also involved in its overall anti-CSC impact. Effectively augments AraC (Cat. No. 251010) in inhibiting primary AML in vitro colony formation (by 79%, 55%, and 100%, respectively, with 10 µM Thioridazine, 0.1 µM AraC, or a combination of both).
产品信息
Form Off-white solid
Molar mass 407.0
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility H2O
Chemical formula C21H26N2S2 •HCl
CAS number 130-61-0
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Regulatory Review |