InSolution™ Cyclopamine-KAAD 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available. 产品信息 Form Liquid Formulation A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO. Primary Target SmoA1 Molar mass 698 Protect from Light 是的 Hygrocopic 是的 Avoid freeze/thaw 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥70% by HPLC (sum of two isomers) 商店和运输信息 Storage ≤ -70°C Ship Dry Ice Only Irritant 安全标示 S Phrase S: 26-36/37/39 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. R Phrase R: 36/38 Irritating to eyes and skin.