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AZD8055
A potent, ATP-competitive inhibitor of mTOR kinase
Product Overview
Product Name: AZD8055
Alternate Name/Synonyms: 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Description: A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC₅₀ of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 µM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1009298-09-2
Molecular Formula: C₂₅H₃₁N₅O₄
Molecular Weight: 465.54
Purity: ≥98% by HPLC
Solubility:DMSO (100 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C
InChi: InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
InChi Key: KVLFRAWTRWDEDF-IRXDYDNUSA-N
PubChem CID: 25262965
MDL Number: MFCD16660191
USAGE: For Research Use Only! Not For Use in Humans. |