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Traut's Reagent
A useful reagent for converting primary amine functional groups into free sulfhydryl groups
Product Overview
Product Name: Traut's Reagent
Alternate Name/Synonyms: 2-Iminothiolane HCl; 2-IT; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl
Description: KEY FEATURES & APPLICATIONS:
• Water-soluble
• Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance
• The spacer is cleavable at the disulfide bond with reducing agent, such as DTT, TCEP, etc.
• Commonly used to convert primary amines into sulfhydryl groups in a one-step process is called thiolation
• Amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides
• Useful RNA-protein crosslinking reagent.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 4781-83-3
Molecular Formula: C₄H₇NS•HCl
Molecular Weight: 137.63
Purity: ≥90% by NMR
Solubility:H2O or aqueous buffers
Storage Temp.: +4 ̊C
Shipping Conditions: Gel Pack
Handling: Protect from moisture
SMILES: C1CC(=N)SC1.Cl
InChi: InChI=1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
InChi Key: ATGUDZODTABURZ-UHFFFAOYSA-N
PubChem CID: 13166855
MDL Number: MFCD00039013
USAGE: For Research Use Only! Not For Use in Humans. |