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ICG-001
A specific inhibitor of Wnt/β-catenin signaling pathway
Product Overview
Product Name: ICG-001
Alternate Name/Synonyms: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Description: A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 847591-62-2
Molecular Formula: C₃₃H₃₂N₄O₄
Molecular Weight: 548.63
Purity: ≥98% by HPLC
Solubility:DMSO (~50 mg/ml) or EtOH (~25 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
InChi: InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1
InChi Key: HQWTUOLCGKIECB-XZWHSSHBSA-N
PubChem CID: 11238147
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |