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LSD1 (aa 400-450) Antibody
Polyclonal antibody to detect LSD1 (a lysine-specific histone demethylase) in Human, Mouse, Chimpanzee, Bovine, Canine and Monkey samples
Product Overview
Product Name: LSD1 (aa 400-450) Polyclonal Antibody
Antibody Target: LSD1
Alternative Name: Lysine-specific histone demethylase 1A (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide from a portion of human LSD1 amino acids 400-450
Accession#: O60341
Gene ID: 23028
Appearance: Colorless liquid
Concentration: N/A
Formulation: 50 μg of antibody in 100 μl PBS containing 0.05% BSA and 0.05% sodium azide.
Purification: Protein G purified
Species Reactivity: Human, mouse, chimpanzee, bovine, canine, monkey
Application: Western blot
Positive Control: Western blot: Jurkat cell lysate, NIH 3T3 cell lysate
Application & Usage: Western blot: 1-3 μg/ml. However, the optimal conditions should be determined individually.
Storage Temp.: -20 °C
Shipping: Gel Pack
Background Descriptions: LSD1 the first known lysine-specific histone demethylase, is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that that LSD1 plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2, LSD1 serves as a novel biomarker predictive for prostate cancer.
USAGE: For Research Use Only! Not For Use in Humans. |