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TTP Antibody
Polyclonal Antibody to detect TTP in human, mouse and rat samples
Product Overview
Product Name: TTP Antibody
Antibody Target: TTP
Alternative Name: G0/G1 switch regulatory protein 24, Growth factor-inducible, nuclear protein NUP475, Protein TIS11A, Zinc finger protein 36 homolog
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide at C-terminal
Accession#: P26651
Gene ID: 7538
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
Purification: Affinity purified
Species Reactivity: Human, mouse, rat
Application: Western blot
Positive Control: Western blot: Jurkat cell lysate
Application & Usage: Western blot: 1:200
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: Tristetraprolin (TTP), also known as Nup475 and TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. Stimulation of quiescent fibroblasts by mitogens, including platelet derived growth factor and fibroblast growth factor, results in the serine phosphorylation of TTP and the rapid redistribution of the protein from the nucleus to the cytoplasm. in vitro studies have demonstrated that TTP is phosphorylated by p42 MAP kinase, indicating that the activity of TTP may be regulated by the MAP kinase pathway in vivo. Knockout mice deficient in TTP develop autoimmunity, inflammatory arthritis and dermatitis. These conditions can be reversed by blocking the activity of the inflammatory mediator, tumor necrosis factor-alpha (TNF-α), suggesting that TTP may function to negatively regulate the expression of TNF-α.
Handling: The antibody solution should be gently mixed before use
USAGE: For Research Use Only! Not For Use in Humans. |