|
Human Recombinant UCHL1
A deubiquitinating enzyme
Product Overview
Product Name: Human Recombinant UCHL1
Alternate Name/Synonyms: Ubiquitin carboxyl-terminal esterase L1, UCHL1, PARK5, Uch-L1.
Gene Symbol: UCHL1
Accession #: P09936
Gene ID: 7345
Source: E. coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM EDTA.
Molecular Weight: 24.8 kDa (223 aa)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity: > 300 pmole/min/ug
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel Pack
Background Information: PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Recombinant PGP9.5 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Amino Acid Sequence: MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |