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Human Recombinant PTP1B
A negative regulator of the insulin signaling pathway
Product Overview
Product Name: Human Recombinant PTP1B
Alternate Name/Synonyms: Protein tyrosine phosphatase, non-receptor type 1, PTPN1, Protein-tyrosine phosphatase 1B, Human Recombinant PTP1B
Gene Symbol: PTPN1
Accession #: P18031
Gene ID: 5770
Source: E. coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in 25 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 2 mM β mercaptoethanol, 1 mM EDTA, 20% Glycerol.
Molecular Weight: 37.3 kDa (321 amino acids)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 6,000-12,000 units/mg
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel Pack
Background Information: The protein coding region of the catalytic domain of PTP-1B (amino acids 1-321) was cloned into an E. coli expression vector. The catalytic domain of PTP-1B was overexpressed in E. coli as a soluble protein, and it was purified by conventional column chromatographic techniques.
Amino Acid Sequence: MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML RVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH N
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |