PPAR Agonist IX, GQ-16

PPAR Agonist IX, GQ-16
(Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione
A cell-permeable thiazolidinedione that acts as a PPARγ-selective agonist (Ki = 160 nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARγ β-sheet structure, exhibiting no detectable activity towards PPARα, PPARδ, or RXRα. Although a weaker PPAPγ agonist than Thiazolidinediones (TZDs) family rosiglitazone (Cat. No. 557366; Max. fold of transactivation induction = 8.57 and 24.8 with 10 µM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20 mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4 mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs.
产品信息
Form  Pale yellow solid
Primary Target  PPARγ
Molar mass  418.3
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥99% by HPLC
Solubility  DMSO
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Harmful