Hh Signaling Antagonist XII, MRT-83 A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine (Cat. No. 239803) and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14 nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50 = 15 nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG-(Cat. Nos. 566660 & 566661) induced C3H10T1/2 cell differentiation (IC50 = 10 nM in an alkaline phosphatase activity assay). Inhibits ShhN (3 nM) and SAG (10 nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~ 3 and 6 nM, respectively). 产品信息 Form Yellowish-white solid Molar mass 538.6 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥98% by HPLC Solubility DMSO Chemical formula C31H30N4O5 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling
