GPR40 Antagonist, GW1100 A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. 产品信息 Form White powder Molar mass 520.6 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C27H25FN4O4S CAS number 306974-70-9 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling
