STAT3 Inhibitor VI, S3I-201

STAT3 Inhibitor VI, S3I-201
2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Also available as a 50 mM solution in DMSO (Cat. No. 573130).
产品信息
Form  Light beige solid
Molar mass  365.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C16H15NO7S
CAS number  501919-59-1
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Regulatory Review