NMDAR2C/2D Inhibitor, DQP-1105

 NMDAR2C/2D Inhibitor, DQP-1105
DQP-1105, NMDA Antagonist IV
A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
产品信息
Form  Yellow-white solid
Molar mass  558.42
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO
Chemical formula  C29H24BrN3O4
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review