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GSK-3β Inhibitor XXIV
2-Methyl-5-(3-[4-(methylsulfinyl)phenyl)-1-benzofuran-5-yl)-1,3,4-oxadiazole, Racemic
The racemic mixture of a cell-permeable oxadiazolo-benzofuranylphenylsulfoxide that inhibits GSK-3β (IC50 = 35, 34, and 140 nM using the racemate, the (S), and the (R) enantiomer, respectively) in a highly selective manner. The eutomer is shown to be orally active in rats and mice and significantly reduce CWS-induced brain tau Thr205 phosphorylation in mice in vivo.
产品信息
Form White solid
Molar mass 338.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C18H14N2O3S
CAS number 1005201-24-0
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |