ARE Activator, BTZO-1

ARE Activator, BTZO-1
2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, Antioxidant Response Element Activator, Macrophage Migration Inhibitory Factor Antagonist II, MIF Antagonist II
A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (Kd = 68.6 nM and 157 nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30 µM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330 nM) from apoptotic death upon serum deprivation or DOX (200 nM; Cat. No. 324380) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner.
产品信息
Form  Off-white solid
Molar mass  240.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥98% by HPLC
Solubility  DMSO
Chemical formula  C13H8N2OS
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review