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Amifostine
2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
产品信息
Form Off-white solid
Molar mass 268.3
Protect from Light 是的
Protect from Moisture 是的
Packaged under inert gas 是的
Purity ≥99% by NMR
Solubility H2O
Chemical formula C5H15N2O3PS •3H2O
CAS number 20537-88-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful
安全标示
R Phrase R: 22
Harmful if swallowed. |